Compensatory mechanism of adaptive responses to interval hypoxia
Cardiovascular system
- Improves microcirculation [Belyavskiy et al., Bobyleva et al., Ischuk et al.,Townsend et al.]
- Reduces endothelial dysfunction Chiu et al. , Elchaninova et al., Haider et al., Manukhina et al.]
- Increases myocardium and brain resistance to acute ischaemia (precondition-like effect) [Bulgaket al., Zhua et al.]
- Reduction in negative consequences of systemic oxidative stress Arkhipenko et al., Borukaeva et al., Elchaninova et al.]
Respiratory system
- Increases lung diffusion capacity for CO2 and O2 [Vogtel et al.]
- Increases ventilatory response [Hetzler et al., Katayama et al.]
- Improves respiratory function [Ainslie et al. , Bobyeva et al., Borukaeva et al., Katayama et al.]
- Improves bronchial performance [Ainslie et al. , Borukaeva et al.]
- Increases baroreflex sensitivity [Haider et al.]
Cellular and metabolic
- HIF-1-alpha, HIF-3-alpha, VEGF, EPO, NOS expression [Ferrara et al., Semenza ]
- Induction of defense protein synthesis (HSP, Fe-RP, repair enzymes) [Arkhipenko et al.]
- Increases glycolic enzymes [Fenkci et al.]
- Improves sensitivity [Lusina et al. , Mackenzie et al. ]
- Increases glucose transporter GLUT-4 [Chiu et al. , Townsend et al.]
- Lowers cholesterol levels [Glazachev et al., Lyapkov et al., Sokolov et al.]
- Anti-inflammatory effect [Anderson et al., Serebrovskaya et al.]
